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Dopamine pain and pleasure8/5/2023 ![]() ![]() PART I - The Pursuit of Pleasure CHAPTER 1 - Our ** MachinesĪddiction broadly defined is the continued and compulsive consumption of a substance or behavior (gambling, gaming, sex) despite its harm to self and/or others. In essence, the secret to finding balance is combining the science of desire with the wisdom of recovery. This book offers practical solutions for how to manage compulsive overconsumption in a world where consumption has become the all-encompassing motive of our lives. Whether it’s sugar or shopping, voyeuring or vaping, social media posts or The Washington Post, we all engage in behaviors we wish we didn’t, or to an extent we regret. Who better to teach us how to overcome compulsive overconsumption than those most vulnerable to it: people with addiction. We also need the lived experience of human beings. This book aims to unpack the neuroscience of reward and, in so doing, enable us to find a better, healthier balance between pleasure and pain. That moment of wanting is the brain’s pleasure balance tipped to the side of pain. We’ve all experienced that moment of craving a second piece of chocolate, or wanting a good book, movie, or video game to last forever. Further, pleasure and pain work like opposite sides of a balance. In addition to the discovery of dopamine, one of the most remarkable neuroscientific findings in the past century is that the brain processes pleasure and pain in the same place. The more dopamine in the brain’s reward pathway, the more addictive the experience. Scientists rely on dopamine as a kind of universal currency for measuring the addictive potential of any experience. If you haven’t met your drug of choice yet, it’s coming soon to a website near you. The smartphone is the modern-day hypodermic needle, delivering digital dopamine 24/7 for a wired generation. the increased numbers, variety, and potency of highly rewarding stimuli today is staggering. Most important, it’s about the relationship between pleasure and pain, and how understanding that relationship has become essential for a life well lived.īecause we’ve transformed the world from a place of scarcity to a place of overwhelming abundance: Drugs, food, news, gambling, shopping, gaming, texting, sexting, Facebooking, Instagramming, YouTubing, tweeting . . . 01:28:20 Laser Photobiomodulation, Protocol 7: Hypnosis (reveri.INTRODUCTION - The Problem Feelin’ good, feelin’ good, all the money in the world spent on feelin’ good.01:17:27 Acupuncture: Mechanism, Non-Responders, Itch & Inflammation.01:12:24 Protocol 6: Agmatine, S-adenosyl-L-methionine (SAMe), L-5-Methyltetrahydrofolate*.01:04:40 Fibromyalgia, Naltrexone, Protocol 5: Acetyl-L-Carnitine.01:01:00 Pain “Syndromes”, Psychogenic Fever, “Psychosomatics”.00:58:08 Sensing Disparate Body Parts As Merged.00:52:04 Protocol 4: Plasticity of Pain: Key Role of Vision.00:40:27 Protocol 2: Cold Sensing Is Relative Getting Into Cold Water.00:33:45 Expectations, Anxiety, & Pain Threshold.00:28:11 Thoughts & Genes That Make Physical Pain Worse.00:22:16 Two-Point Discrimination, Dermatomes.00:18:13 Sensing Touch with Your Brain: Magnification of Feet, Hands, Lips, Face, Genitals.00:12:04 Pleasure & Pain, & Skin Sensors.00:07:12 Sponsors: InsideTracker, Helix Sleep, Athletic Greens. ![]() 00:01:50 Protocol 1: Maximizing Motivation (with Dopamine & Pleasure).For an excellent full-text review of this anatomy and circuits for touch sensing, please read this article. Note: The description of the dorsal root ganglia (DRGs) was intentionally simplified and does not include mention of dorsal horn spinal relay neurons, etc. As always, both basic science and various protocols are described. Finally, I address the link between dopamine, serotonin, and oxytocin with arousal, pleasure and pain. He discusses neuroplasticity of the pain system and the key role that visual perception plays in pain modulation. Huberman also discusses whole body pain, pain “syndromes” and novel pain relief compounds such as Acetyl-L-Carnitine, SAMe and Agmatine. He discusses the science of behavioral tools like acupuncture and hypnosis and directed pressure, including the neural circuits they each activate to modulate our experience of pain or pleasure. Huberman discusses our sense of pain and pleasure: where and how they each arise in our mind and body and various ways to control their intensity. Listen: YouTube | Apple Podcasts | Spotify ![]()
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